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Genomic and clinical data from the InterGEN cohort (n = 227) were used. In this secondary analysis, we examined associations between age acceleration depressive symptoms and CM traits (hypertension, diabetes mellitus, and obesity) in a cohort of AAW.
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Depressive symptoms co-occur in individuals with CM illness at higher rates than the general population, and accelerated aging may explain this. We conclude with suggestions for novel mechanism-based therapeutics based on these mediators.Īfrican American women (AAW) have a high risk of both cardiometabolic (CM) illness and depressive symptoms. These factors interact in increasing the likelihood of physical disease and of accelerated aging at the cellular level. In this model, MDD is characterized by a surfeit of potentially destructive mediators and an insufficiency of protective or restorative ones.
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We then focus on several interlinked mediators occurring in MDD (or at least in subtypes of MDD) that may contribute to the medical comorbidity burden and to accelerated aging: limbic-hypothalamic-pituitary-adrenal axis alterations, diminution in glucocorticoid receptor function, altered glucose tolerance and insulin sensitivity, excitotoxicity, increases in intracellular calcium, oxidative stress, a proinflammatory milieu, lowered levels of "counter-regulatory" neurosteroids (such as allopregnanolone and dehydroepiandrosterone), diminished neurotrophic activity, and accelerated cell aging, manifest as alterations in telomerase activity and as shortening of telomeres, which can lead to apoptosis and cell death. We first review the moderating effects of psychological styles of coping, genetic predisposition, and epigenetic modifications (eg, secondary to childhood adversity). These are conditions that typically occur late in life, and it has been suggested that MDD may be associated with "accelerated aging." We review several moderators and mediators that may accompany MDD and that may give rise to these comorbid medical conditions.
IN SOUND MIND AGE RATING SERIES
Explore and fight through a series of unsettling memories as you journey within the inner workings of the one place you can’t seem to escape-your own mind.Major depressive disorder (MDD) is associated with a high rate of developing serious medical comorbidities such as cardiovascular disease, stroke, dementia, osteoporosis, diabetes, and the metabolic syndrome. In Sound Mind is a witty first-person psychological horror with frenetic puzzles, unique boss fights, and original music by The Living Tombstone. With your sanity in question, you have no choice but to rely on your instinct…and a cat named Tonia.
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In your search for answers, bizarre visions emerge and introduce a host of imposing horrors. As you awake in the corridors of an inexplicable building, you find the environment takes on a life of its own and leads you to discover a series of victims, all exposed to the same experimental therapy. As you awake in the corridors of an inexplicable building, you find the environment takes on a From the creators of cult classic Nightmare House 2, comes an imaginative psychological horror experience that challenges your expectations and ushers you through the deepest corners of your mind. Summary: From the creators of cult classic Nightmare House 2, comes an imaginative psychological horror experience that challenges your expectations and ushers you through the deepest corners of your mind.